What to Expect from Your First Spravato Session

Spravato® (esketamine) is an in-clinic nasal spray for adults with treatment-resistant depression that can act quickly for some people. Because it affects perception and blood pressure in the short term, Spravato is given under clinical supervision with a required observation period after dosing. This guide walks you through the typical first visit so you arrive prepared and confident.
Is Spravato right for you?
Spravato is intended for adults whose depression hasn’t responded to adequate trials of antidepressant medications and psychotherapy. Your clinician will review your treatment history and current medical status to determine candidacy. If you’re considering Spravato, Redbud offers a free 20-minute clinician consult to review fit and logistics.
The Visit
1. Pre-visit screening & evaluation
Before your first dose, you’ll have an evaluation with a clinician to confirm Spravato is appropriate and safe. This includes:
- A psychiatric review (symptom history, previous treatments).
- Medical screening (blood pressure, cardiovascular history, current medications, pregnancy status, substance use).
- Discussion of risks, benefits, and the observation and driving restrictions that follow dosing.
Redbud runs benefits checks and discusses likely costs before you book, if insurance may apply.
2. Arrival & baseline checks
On the day of dosing, you’ll check in, present ID/insurance if applicable, and the team will take baseline vitals (especially blood pressure) and confirm you’re ready for dosing.
3. Dosing - supervised nasal administration
- Spravato is given as a nasal spray in the clinic and administered under clinician supervision.
- The clinician will walk you through how the spray is used and will supervise the dosing session.
4. Post-dose observation (required)
- After dosing, you’ll stay in the clinic for a monitored observation period. Clinicians will check your vitals and ensure you’re medically stable before discharge.
- Because of potential acute effects, you will NOT be allowed to drive the same day; you must arrange a responsible adult to accompany you home.
How long will the visit take?
Plan for roughly 2–3 hours for your first Spravato visit (evaluation + dosing + observation). Exact timing varies by protocol and by how you tolerate the dose.
Common short-term effects & safety
Common: Dissociation, dizziness, nausea, sleepiness, transient increases in blood pressure. These are usually short-lived and are monitored in the clinic.
Safety checks: Clinics monitor vitals and are prepared to manage short-term reactions. People with uncontrolled hypertension, certain cardiovascular conditions, or other specific medical issues may not be candidates - your clinician will review this during screening.
No driving same day: Because of transient impairment, driving is not permitted the day of treatment. Plan transportation and time off accordingly.
Practical Tips - What to Bring & How to Plan
- Bring: Photo ID, insurance card (if using insurance), a list of current medications and doses, and any recent medical records that might be relevant.
- Arrange transport: You must have a responsible adult to drive you home. Public transit or rideshare without a companion is not advised.
- Clothing & comfort: Wear comfortable clothes and bring something to help pass the observation time (book, headphones).
- Food & meds: Eat a light meal beforehand unless instructed otherwise. Continue routine prescription medications unless told otherwise by the clinician.
- Plan recovery time: Block the rest of the day for recovery and avoid important tasks (driving, critical work) after the visit.
Cost & Coverage Differences
Coverage for Spravato varies widely by insurer. Redbud performs benefit checks and manages prior authorization when coverage is possible, and will provide a written estimate of expected patient responsibility. If coverage is not available, Redbud will discuss self-pay costs and financing options.
Combining Spravato with other treatments
Spravato is often used as part of a broader care plan - alongside an oral antidepressant, psychotherapy, and sometimes neuromodulation like TMS. Redbud coordinates care across treatments to maximize safety and effectiveness. Decisions about combining Spravato with other therapies are individualized.
How fast does Spravato work?
Some patients notice changes within hours to days; benefits often accumulate across repeated sessions. Individual response varies.
Can I continue my current medications and therapy?
Often yes — Spravato is usually given alongside an oral antidepressant and psychotherapy. Your clinician will review medication interactions and coordinate care.
Is Spravato safe?
When given in-clinic with proper screening and monitoring, Spravato is generally safe. Clinics monitor blood pressure, dissociative effects and other short-term reactions. Your clinician will review risks and why Spravato may or may not be appropriate for you.
Will insurance pay?
Coverage varies. Redbud runs benefit checks and manages prior authorizations when appropriate so you know likely out-of-pocket costs before starting.















